Ampicillin sodium
CAS No. 69-52-3
Ampicillin sodium ( Alpen-N, Amcill-S, Ampicillin natrium, Ampicillin sodium )
产品货号. M15658 CAS No. 69-52-3
氨苄西林对于缓解 11 周龄猪的出血性肠炎症状非常有效。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 1G | ¥405 | 有现货 |
|
生物学信息
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产品名称Ampicillin sodium
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述氨苄西林对于缓解 11 周龄猪的出血性肠炎症状非常有效。
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产品描述Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia.(In Vitro):Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL.(In Vivo):Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia.
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体外实验Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL.
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体内实验Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia.
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同义词Alpen-N, Amcill-S, Ampicillin natrium, Ampicillin sodium
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通路GPCR/G Protein
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靶点Antibacterial
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受体β-Lactamase
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研究领域Infection
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适应症——
化学信息
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CAS Number69-52-3
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分子量371.39
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分子式C16H18N3N/AO4S
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纯度>98% (HPLC)
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溶解度DMSO:37 mg/mL (99.62 mM); Ethanol:74 mg/mL (199.25 mM); Water:74 mg/mL (199.25 mM)
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SMILESN(C(=O)[C@@H](c1ccccc1)N)[C@H]1[C@@H]2N(C1=O)[C@H](C(S2)(C)C)C(=O)[O-].[Na+]
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化学全称4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, monosodium salt, (2S-(2alpha,5alpha,6beta(S*)))-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7.
2. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5.
3. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92.
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